Table 5.
The association of SNPs with CAD risk in dominant inheritance mode.
Gene | SNPs genotype | CAD positive n (%) | CAD negative n (%) | OR (95% CI) | p | OR′ (95% CI′) | p′ |
---|---|---|---|---|---|---|---|
GIP | rs2291725 | ||||||
C/C | 187 (48.6) | 102 (37.5) | |||||
C/T + T/T | 198 (51.4) | 170 (62.5) | 0.635 (0.463–0.872) | 0.005 | 0.769 (0.626–0.945) | 0.013 | |
rs8078510 | |||||||
G/G | 281 (73.2) | 174 (64.7) | |||||
G/A + A/A | 103 (26.8) | 95 (35.3) | 0.671 (0.479–0.940) | 0.020 | 0.762 (0.612–0.949) | 0.015 |
OR′, 95% CI′, and p′ were calculated by logistic regression analysis after adjustment for other known CAD risk factors (age, BMI, smoking status, dyslipidemia history, hypertension history, and diabetic duration).