Table 9.
Genotype distributions of GIP SNPs in male < 55 y and female < 65 y in dominant inheritance mode.
| Gene | SNPs genotype | CAD positive n (%) | CAD negative n (%) | OR (95% CI) | p | OR′ (95% CI′) | p′ |
|---|---|---|---|---|---|---|---|
| GIP | rs2291725 | ||||||
| C/C | 55 (51.4) | 44 (34.9) | 1.971 (1.164–3.339) | 0.011 | 1.346 (0.958–1.892) | 0.087 | |
| C/T + T/T | 52 (48.6) | 82 (65.1) | |||||
| rs8078510 | |||||||
| G/G | 85 (79.4) | 77 (62.1) | 2.358 (1.304–4.266) | 0.004 | 1.589 (1.071–2.357) | 0.021 | |
| G/A + A/A | 22 (20.6) | 47 (37.9) |
OR′, 95% CI′, and p′ were calculated by logistic regression analysis after adjustment for other known CAD risk factors (age, BMI, smoking status, dyslipidemia history, hypertension history, and diabetic duration).