Table 2.
Effect of M. citrifolia leaf extract on the oxidative stress status including the level of malondialdehyde (MDA) and the activities of main scavenger enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in the cerebral cortex of OVX rats which were subjected to MCAO (N = 6/group). aaap value < 0.001 compared to OVX + sham operation group. ∗p value < 0.05 and ∗∗∗p value < 0.001, respectively, compared to OVX + MCAO group.
| Treatment | MDA (nm/mg protein) | SOD (unit/mg protein) | CAT (unit/mg protein) | GPx (unit/mg protein) |
|---|---|---|---|---|
| OVX + sham operation | 0.97 ± 0.16 | 25.13 ± 8.20 | 25.45 ± 8.88 | 3.45 ± 0.92 |
| OVX + MCAO | 2.96 ± 0.30aaa | 14.27 ± 2.65 | 18.03 ± 5.98 | 1.96 ± 0.29 |
| OVX + MCAO + genistein | 2.79 ± 0.06 | 13.86 ± 1.14 | 6.42 ± 0.63 | 2.68 ± 0.76 |
| OVX + MCAO + M. citrifolia (2 mg/kg) | 2.51 ± 0.72 | 34.65 ± 6.83∗ | 22.26 ± 0.80 | 6.00 ± 1.03∗ |
| OVX + MCAO + M. citrifolia (10 mg/kg) | 2.58 ± 0.35 | 21.85 ± 3.14 | 25.54 ± 5.83 | 4.24 ± 0.24 |
| OVX + MCAO + M. citrifolia (50 mg/kg) | 0.24 ± 0.05∗∗∗ | 25.22 ± 5.54 | 22.82 ± 4.30 | 4.76 ± 0.11 |