Figure 3.

FR3 inhibited wound closure of the HeLa cell monolayer after 72 hours of treatment (a) in 70% (p ≤ 0.05) and decreased the expression of active MMP-2 in the supernatant of these cells (b). FR3 inhibited the migration of HeLa cells (15 ug/ml and 30 ug/ml) by the Boyden Chamber assay, as well as treatment with Cisplatin (15 ug/ml) for 24 hours (c) and inhibited the invasion of HeLa cells treated for 24 hours using Matrigel (d). The significant difference with p ≤ 0.05 values. ∗∗∗  indicates statistically significant differences between treatment and control with value of p ≤ 0.001. ∗∗  indicates statistically significant differences between treatment and control with value of p ≤ 0.005. ∗  represents the significant difference with a value of p ≤ 0.05. Different letters indicate statistically significant differences between each treatment with p ≤ 0.0001.