Table 2.
Associations of HIF-1α and AEG-1 levels with clinicopathologic features of EOC patients.
| Variable | Cases (N) | AEG-1 high levels | HIF-1α high levels | ||
|---|---|---|---|---|---|
| n (%) | p | n (%) | p | ||
| Age | 0.271 | 0.697 | |||
| ≤55 | 63 | 43 (68.3) | 39 (61.9) | ||
| >55 | 107 | 64 (59.8) | 63 (58.9) | ||
| Metastasis | 0.005 | 0.001 | |||
| Negative | 28 | 11 (39.3) | 9 (32.1) | ||
| Positive | 142 | 96 (67.6) | 93 (65.5) | ||
| Histological type | 0.002 | 0.006 | |||
| Serous | 111 | 79 (71.2) | 75 (67.6) | ||
| Others | 59 | 28 (47.5) | 27 (45.8) | ||
| Grade | 0.644 | 0.035 | |||
| G1-2 | 101 | 65 (64.4) | 54 (53.5) | ||
| G3 | 69 | 42 (60.9) | 48 (69.6) | ||
| FIGO stage | 0.000 | 0.001 | |||
| I-II | 45 | 19 (42.2) | 18 (40.0) | ||
| III-IV | 125 | 88 (70.4) | 84 (67.2) | ||
| Residual tumor (cm) | 0.000 | 0.000 | |||
| ≤1 | 81 | 37 (45.7) | 34 (42.0) | ||
| >1 | 89 | 70 (78.7) | 68 (76.4) | ||
| Ascites (ml) | 0.008 | 0.019 | |||
| ≤500 | 62 | 31 (50.0) | 30 (48.4) | ||
| >500 | 108 | 76 (70.4) | 72 (66.7) | ||
| Menopausal status | 0.251 | 0.094 | |||
| No | 55 | 38 (69.1) | 38 (69.1) | ||
| Yes | 115 | 69 (60.0) | 64 (55.7) | ||
| Preoperative CA125 level (U/ml) | 0.913 | 0.820 | |||
| ≤35 | 14 | 9 (64.3) | 8 (57.1) | ||
| >35 | 156 | 98 (62.8) | 94 (60.3) | ||
| Chemo. | 0.261 | 0.648 | |||
| No | 61 | 35 (57.4) | 38 (62.3) | ||
| Yes | 109 | 72 (66.1) | 64 (58.7) | ||