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. Author manuscript; available in PMC: 2018 Apr 8.
Published in final edited form as: Cell Metab. 2016 Oct 13;24(5):728–739. doi: 10.1016/j.cmet.2016.09.005

Figure 3. Metabolite changes are shared by patient and mouse in response to metformin treatment.

Figure 3

A. Disease free days of ten patients on metformin. The long term survivor patient is the one with longest disease free days shown in green. B. Number of metabolites overlapped in patients and mouse tumor with larger effects in the metformin treatment group (fold change >2 or <0.6). This number indicates the number of metabolites with changes in response to metformin treatment. C. Representative metabolites sharing similar changes in response to metformin treatment in mouse (p<0.1, * p<0.05, ** p<0.01) and a long term survivor patient tumor. Error bars obtained from SEM of n=5 independent measurements.