Figure 2.

Effect of different diagnostic approaches on numbers of ACTH stimulation tests in patients suspected of adrenal insufficiency. Current protocols are considered the reference (A). An approach with a second plasma cortisol measurement, in addition to the plasma cortisol requested by the referring physician, is shown in panel B. Panel C displays an approach including salivary cortisol measurements. Percentages of patients with AI ruled out or established are given, as well as the percentage of ACTH stimulation tests performed using the different approaches in B and C.