Table 1. Baseline characteristics of Korean patients with hyponatremia caused by SIADH, and changes in serum sodium concentration during the study period.
| Variables | Values (n = 39) | |
|---|---|---|
| Age, yr | 70.8 ± 11.3 (22–87) | |
| Height, cm | 160.9 ± 8.4 (146–176) | |
| Weight, kg | 57.1 ± 10.0 (40–95) | |
| BMI, kg/m2 | 22.1 ± 3.1 (14.7–32.5) | |
| Female (%) | 16 (41%) | |
| Cr, mg/dL | 0.66 ± 0.22 (0.3–1.1) | |
| AST, IU/L | ||
| AST (initial) | 22.9 ± 8.1 (21–55) | |
| AST (11 days) | 23.1 ± 5.7 (14–37) | |
| ALT, IU/L | ||
| ALT (initial) | 19.3 ± 13.8 (6–76) | |
| ALT (11 days) | 19.3 ± 10.8 (7–51) | |
| Na, mmol/L | ||
| Na (initial) | 126.8 ± 4.3 (116–134) | |
| Na (4 hours) | 129.6 ± 4.4a (121–137) | |
| Na (8 hours) | 132.7 ± 4.6b (124–141) | |
| Na (24 hours) | 133.7 ± 3.8c (127–143) | |
| Na (4 days) | 135.6 ± 3.6d (126–141) | |
| Na (11 days) | 136.7 ± 4.5 (120–142) | |
| Na (18 days) | 128.7 ± 8.8e (106–139) | |
| ΔNa, mmol/L | ||
| ΔNa (4 hours) | 2.8 ± 3.3 (−5–10) | |
| ΔNa (8 hours) | 5.9 ± 4.1 (−1–15) | |
| ΔNa (24 hours) | 6.8 ± 4.2 (−1–17) | |
| The changes of average AUC (4 days) | 8.1 ± 3.9 (2–16) | |
Data are presented as means ± SDs (range) or number (%).
SIADH = syndrome of inappropriate secretion of antidiuretic hormone, BMI = body mass index, Cr = creatinine, AST = aspartate aminotransferase, ALT = alanine aminotransferase, Na = serum sodium level, ΔNa = the change in serum sodium level, AUC = area under curve, SD = standard deviation.
aP < 0.001, 0 hours vs. 4 hours; bP < 0.001, 4 hours vs. 8 hours; cP < 0.05, 8 hours vs. 24 hours; dP < 0.05, 24 hours vs. 4 days; eP < 0.001, 11 days vs. 18 days.