Table 2. Effect of TLV on serum sodium in patients with severe, moderate or mild hyponatremia.
| Variables | < 125 mmol/L (n = 9, 23%) | 125–129 mmol/L (n = 18, 46%) | 130–134 mmol/L (n = 12, 31%) | P value | |
|---|---|---|---|---|---|
| Age, yr | 67.1 ± 9.0 (59–85) | 70.1 ± 13.5 (22–87) | 74.7 ± 8.3 (58–84) | 0.115 | |
| Height, cm | 161.1 ± 9.5 (147–73) | 162.0 ± 7.4 (151–175) | 158.7 ± 9.4 (146–176) | 0.607 | |
| Weight, kg | 56.4 ± 7.7 (48–73) | 60.7 ± 11.4 (47–95) | 51.9 ± 6.9 (40–62) | 0.063 | |
| BMI, kg/m2 | 21.8 ± 2.8 (16.2–25.5) | 23.0 ± 3.1 (19.6–32.5) | 20.7 ± 3.1 (14.7–23.9) | 0.379 | |
| Female, % | 2 (22%) | 5 (28%) | 9 (75%) | 0.015 | |
| Na, mmol/L | |||||
| Na (initial) | 120.6 ± 2.4 (116–123) | 126.9 ± 1.5 (125–129) | 131.4 ± 1.3 (130–134) | < 0.001 | |
| Na (4 hours) | 125.3 ± 3.2 (121–131) | 129.6 ± 3.2 (124–135) | 132.9 ± 4.0 (125–137) | 0.001 | |
| Na (8 hours) | 128.6 ± 3.4 (124–135) | 132.9 ± 4.2 (128–140) | 135.6 ± 4.0 (129–141) | 0.002 | |
| Na (24 hours) | 131.7 ± 3.8 (127–138) | 133.4 ± 3.4 (128–138) | 135.7 ± 3.6 (132–143) | 0.124 | |
| Na (4 days) | 133.3 ± 3.9 (126–139) | 135.3 ± 3.4 (127–140) | 137.9 ± 2.4 (133–141) | 0.011 | |
| Na (11 days) | 132.7 ± 7.3 (120–142) | 137.2 ± 3.0 (131–142) | 138.3 ± 2.7 (134–142) | 0.143 | |
| Na (18 days) | 119.8 ± 10.6 (106–133) | 129.1 ± 8.3 (113–138) | 132.4 ± 5.9 (124–139) | 0.084 | |
| ΔNa, mmol/L | |||||
| ΔNa (4 hours) | 4.8 ± 3.6 (−1–10) | 2.7 ± 2.7 (−2–8) | 1.5 ± 3.4 (−5–5) | 0.154 | |
| ΔNa (8 hours) | 8.0 ± 4.8 (1–15) | 6.1 ± 3.8 (0–13) | 4.2 ± 3.4 (−1–9) | 0.181 | |
| ΔNa (24 hours) | 11.1 ± 4.8a,b (4–17) | 6.4 ± 2.5 (2–9) | 4.3 ± 3.3 (−1–10) | 0.005 | |
Data are presented as mean ± SD (range) or number (%).
TLV = tolvaptan, BMI = body mass index, Na = serum sodium level, ΔNa = the change in serum sodium level, SD = standard deviation.
aP < 0.05, < 125 mmol/L vs. 126–129 mmol/L; bP < 0.01, < 125 mmol/L vs. 130–134 mmol/L.