Table 2.
Blister fluid (BF) immunological characteristics (A) and correlation between serum and BF autoantibody titers (B) in patients with BP according to mucosal involvement.
| All BP patients | Patients without mucosal involvement | Patients with mucosal involvement | Pvalue | |
|---|---|---|---|---|
| (A) | ||||
| Number of patients (n)a | 37 | 30 | 7 | NA |
| BF anti-BP180 NC16A | ||||
| Number of patients with titer ≥9 U/mL, n (%) | 32 (86.5) | 26 (86.7) | 6 (85.7) | 0.95 |
| Mean value ± SD (U/mL) | 79.4 ± 51.2 | 78.5 ± 51.8 | 83.5 ± 52.2 | 0.66 |
| BF anti-BP230 | ||||
| Number of patients with titer ≥9 U/mL, n (%) | 16 (43.2) | 14 (46.7) | 2 (28.7) | 0.38 |
| Mean value ± SD (U/mL) | 31.2 ± 40.3 | 34.2 ± 41.5 | 18.2 ± 34.2 | 0.65 |
| (B) | ||||
| Number of patientsa | 37 | 30 | 7 | |
| Anti-BP180 NC16A | r = 0.78 | r = 0.74 | r = 0.89 | |
| P < 0.0001 | P < 0.0001 | P = 0.01 | ||
| Anti-BP230 | r = 0.73 | r = 0.74 | r = 0.75 | |
| P < 0.0001 | P < 0.0001 | P = 0.07 | ||
Subsets of BP patients with or without mucosal involvement were compared and P-value was calculated using Chi2 tests for comparison between qualitative variables and nonparametric, Mann–Whitney tests for comparison between quantitative values. Spearman’s correlation coefficient was used to explore the relationship between immunological parameters in serum with those in BF.
aPatient for whom BF and serum anti-BP180 NC16A and anti-BP230 ELISA values were available.
NA, not applicable; BP, bullous pemphigoid; ELISA, enzyme-linked immunosorbent assay.