Table 1.
Expression of immune-related genes in E0771/shPlac1 cells. Shown are ≥3.0-fold changes in expression with a raw score ≥300 in either E0771/shPlac1 or E0771/Scr cells.
| Gene | Raw Score | shPlac1/Scr | Function | |
|---|---|---|---|---|
| Scr | shPlac1 | |||
| Cxcl1 | 7054 | 106 | −67 | Cxcr2 ligand |
| Ccl7 | 2854 | 153 | −19 | Ccr3 ligand |
| CD68 | 931 | 55 | −18 | Macrophage phagocytosis |
| Ccl2 | 3640 | 305 | −12 | Ccr2/Ccr5 ligand; MDSC |
| Lif | 664 | 80 | −8.3 | Immune tolerance at maternal−fetal interface |
| C1 | 918 | 128 | −7.1 | Complement |
| Ccl5 | 3812 | 784 | −4.9 | Ccr1/3/4/5 ligand |
| Tsc22d3 | 2265 | 478 | −4.8 | Mediates IL10 immunosuppression |
| Ly6a | 4937 | 1160 | −4.3 | Sca-1; inhibits TGFb, Pten and PPARg |
| Ly6c | 1198 | 329 | −3.7 | Mono/Mφ marker; MDSC |
| Clec2d | 366 | 99 | −3.7 | Protects against NK cells |
| Cxcl10 | 459 | 130 | −3.6 | Cxcr3 ligand |
| CD274 | 302 | 91 | −3.4 | PD-L1; PD-1 ligand |