Table 2.
rs17481869 (2q22.3) genotypes and risk associated with BCP-ALL, high-hyperdiploid, and ETV6-RUNX1 childhood BCP-ALL subtypes
| RAF | Number | ||||||
|---|---|---|---|---|---|---|---|
| All BCP-ALL | Cases | Controls | Cases | Controls | OR | CI | P-value |
| UK GWAS I | 0.08 | 0.07 | 824 | 5200 | 1.18 | (0.95–1.46) | 1.37 × 10−1 |
| German GWAS | 0.10 | 0.08 | 834 | 2024 | 1.25 | (1.01–1.56) | 4.33 × 10−2 |
| UK GWAS II | 0.10 | 0.07 | 784 | 7385 | 1.52 | (1.25–1.84) | 2.53 × 10−5 |
| Combined | 2442 | 14,609 | 1.32 | (1.17–1.49) | 5.36 × 10−6 | ||
| Phet = 0.19 | I2 = 39.3% | ||||||
| High-hyperdiploid | |||||||
| UK GWAS I | 0.06 | 0.07 | 289 | 5200 | 0.86 | (0.61–1.22) | 4.03 × 10−1 |
| German GWAS | 0.08 | 0.08 | 176 | 2024 | 0.98 | (0.64–1.48) | 9.11 × 10−1 |
| UK GWAS II | 0.10 | 0.07 | 251 | 7385 | 1.48 | (1.06–2.08) | 2.13 × 10−2 |
| Combined | 716 | 14,609 | 1.10 | (0.89–1.35) | 0.38 | ||
| Phet = 0.07 | I2 = 62% | ||||||
| ETV6-RUNX1 -positive | |||||||
| UK GWAS I | 0.11 | 0.07 | 126 | 5200 | 2.01 | (1.20–3.39) | 8.52 × 10−3 |
| German GWAS | 0.12 | 0.08 | 63 | 2024 | 1.72 | (0.88–3.38) | 1.14 × 10-1 |
| UK GWAS II | 0.13 | 0.07 | 220 | 7385 | 2.34 | (1.64–3.35) | 2.90 × 10−6 |
| Combined | 409 | 14,609 | 2.14 | (1.64–2.80) | 3.20 × 10−8 | ||
| Phet = 0.70 | I2 = 0% | ||||||
Note: P-values for each individual study were generated using SNPTEST v2.5.2 software. Combined P-values and estimates were obtained using a fixed-effects model using beta values and standard errors. RAF risk allele frequency, OR odds ratio, Phet P heterogeneity, I2 index to quantify dispersion of odds ratio, CI confidence interval