Table 1.
Significantly upregulated proteins during storage (low in control cells).
| Gene Symbol | Gene Description | Biological function |
|---|---|---|
| ACOX1 | Peroxisomal acyl-coenzyme A oxidase 1 | Desaturation of acyl-CoAs to 2-trans-enoyl-CoAs |
| ALDH18A1 | Delta-1-pyrroline-5-carboxylate synthase | Synthesis of proline, ornithine and arginine |
| AP2A1 | AP-2 complex subunit alpha-1 | Component of the adaptor protein complex 2; clathrin-dependent endocytosis |
| ARHGAP1 | Rho GTPase-activating protein 1 | GTPase activator for Rho, Rac and Cdc42 |
| ARMT1 | Protein-glutamate O-methyltransferase | Formation of gamma-glutamyl methyl ester residues |
| BCLAF1 | Bcl-2-associated transcription factor 1 | Death-promoting transcriptional repressor |
| DAZAP1 | DAZ-associated protein 1 | RNA-binding protein; possibly required in spermatogenesis |
| DBI | Acyl-CoA-binding protein | Possible intracellular carrier of acyl-CoA esters |
| DBT | Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial | Conversion of alpha-keto acids to acyl-CoA and CO2 |
| DDX23 | Probable ATP-dependent RNA helicase DDX23 | Pre-mRNA splicing |
| DNAJC3 | DnaJ homolog subfamily C member 3 | Unfolded protein response during endoplasmic reticulum stress |
| DSP | Desmoplakin | Anchoring of intermediate filaments to desmosomes |
| EIF6 | Eukaryotic translation initiation factor 6 | Prevents the association of the 60S ribosomal subunit with the 40S subunit |
| EPM2AIP1 | EPM2A-interacting protein 1 | Unknown |
| EZR | Ezrin | Connection of cytoskeletal structures to the plasma membrane; formation of microvilli |
| FARSB | Phenylalanine–tRNA ligase beta subunit | Regulatory tRNA ligase beta subunit |
| FBN2 | Fibrillin-2 | Component of extracellular calcium-binding microfibrils; regulation of elastic fibers |
| FLOT1 | Flotillin-1 | Possible scaffolding protein within caveolar membranes; formation of caveolae |
| FUCA2 | Plasma alpha-L-fucosidase | Hydrolyzation of glycoproteins |
| GATM | Glycine amidinotransferase, mitochondrial | Synthesis of creatine precursor guanidinoacetate |
| GDAP2 | Ganglioside-induced differentiation-associated protein 2 | Unknown |
| HIST1H4A | Histone H4 | Core nucleosome component |
| HNRNPD | Heterogeneous nuclear ribonucleoprotein D0 | RNA-binding protein |
| HNRNPH1 | Heterogeneous nuclear ribonucleoprotein H | Pre-mRNA processing |
| HNRNPM | Heterogeneous nuclear ribonucleoprotein M | Pre-mRNA binding protein |
| HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | Interconversion of testosterone and androstenedione; estradiol and estrone |
| KIAA1468 | LisH domain and HEAT repeat-containing protein KIAA1468 | Unknown |
| KTN1 | Kinectin | Kinesin-driven vesicle motility |
| LRPPRC | Leucine-rich PPR motif-containing protein, mitochondrial | Nuclear and mitochondrial RNA metabolism |
| LRRC8A | Volume-regulated anion channel subunit LRRC8A | Essential component of the volume-regulated anion channel |
| LRSAM1 | E3 ubiquitin-protein ligase LRSAM1 | Regulation of signaling pathways, cell adhesion, self-ubiquitylation, and cargo sorting during receptor endocytosis |
| MRPL28 | 39S ribosomal protein L28, mitochondrial | Component of the 39S mitochondrial ribosome subunit |
| MRRF | Ribosome-recycling factor, mitochondrial | Release of ribosomes from mRNA |
| MYH9 | Myosin-9 | Cytokinesis, cell shape, secretion |
| MYO7A | Unconventional myosin-VIIa | Intracellular movements |
| NUDT19 | Nucleoside diphosphate-linked moiety X motif 19 | Hydrolysis various CoA esters |
| NUP155 | Nuclear pore complex protein Nup155 | Component of the nuclear pore complex |
| PDHB | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | Conversion of pyruvate to acetyl-CoA and CO2 |
| POLR2E | DNA-directed RNA polymerases I, II, and III subunit RPABC1 | Subunit of RNA polymerase II |
| PRCP | Lysosomal Pro-X carboxypeptidase | Cleavage of C-terminal amino acids |
| PRDX2 | Peroxiredoxin-2 | Involved in redox regulation of the cell |
| PRDX3 | Thioredoxin-dependent peroxide reductase, mitochondrial | Involved in redox regulation of the cell |
| PRKCSH | Glucosidase 2 subunit beta | Beta-subunit of glucosidase II, an ER glycan-processing enzyme |
| PRKDC | DNA-dependent protein kinase catalytic subunit | DNA double-strand break repair |
| PRPF8 | Pre-mRNA-processing-splicing factor 8 | Assembly of spliceosomal proteins |
| PRPS2 | Ribose-phosphate pyrophosphokinase 2 | Synthesis of phosphoribosylpyrophosphate (PRPP), essential for nucleotide synthesis |
| PTCD3 | Pentatricopeptide repeat domain-containing protein 3, mitochondrial | Mitochondrial RNA-binding protein |
| PTPRA | Receptor-type tyrosine-protein phosphatase alpha | Regulation of integrin signaling, cell adhesion and proliferation |
| RAB7A | Ras-related protein Rab-7a | Key regulator in endo-lysosomal trafficking |
| RPL18 | 60S ribosomal protein L18 | Component of the ribosomal 60S subunit |
| RPL37A | 60S ribosomal protein L37a | Component of the ribosomal 60S subunit |
| SLC25A3 | Phosphate carrier protein, mitochondrial | Transport of phosphate groups from the cytosol to the mitochondrial matrix |
| SOSTDC1 | Sclerostin domain-containing protein 1 | Bone morphogenetic protein antagonist |
| SRP54 | Signal recognition particle 54 kDa protein | Transfer of presecretory protein from ribosomes to TRAM (translocating chain-associating membrane protein) |
| STAG2 | Cohesin subunit SA-2 | Component of the cohesin complex |
| SUCLG2 | Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial | Citric acid cycle |
| SULT1A1 | Sulfotransferase 1A1 | Sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters |
| TOR1A | Torsin-1A | Protein folding, processing, stability and localization |
| TRA2B | Transformer-2 protein homolog beta | Pre-mRNA splicing |
| UBA1 | Ubiquitin-like modifier-activating enzyme 1 | Ubiquitin conjugation |
| VPS18 | Vacuolar protein sorting-associated protein 18 homolog | Vesicle-mediated protein trafficking to lysosomal compartments |