Table 2.
Significantly downregulated proteins during storage (high in control cells).
| Gene Symbol | Gene Description | Biological function |
|---|---|---|
| ABCA1 | ATP-binding cassette sub-family A member 1 | Transmembrane transport |
| ATP1A1 | Sodium/potassium-transporting ATPase subunit alpha-1 | Hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane |
| ATP1A3 | Sodium/potassium-transporting ATPase subunit alpha-3 | Hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane |
| ATP6V1C2 | V-type proton ATPase subunit C 2 | Subunit of the vacuolar ATPase |
| CD2AP | CD2-associated protein | Adapter protein between membrane proteins and the actin cytoskeleton |
| COASY | Bifunctional coenzyme A synthase | CoA biosynthetic pathway |
| COPZ1 | Coatomer subunit zeta-1 | Binds dilysine motifs, reversibly associates with Golgi non-clathrin-coated vesicles |
| CTTN | Src substrate cortactin | Organization of the actin cytoskeleton |
| EIF2S2 | Eukaryotic translation initiation factor 2 subunit 2 | Early protein synthesis |
| EIF4A3 | Eukaryotic initiation factor 4A-III | ATP-dependent RNA helicase |
| FAH | Fumarylacetoacetase | Tyrosine catabolism |
| FAM234A | Protein ITFG3/Protein FAM234A | Unknown |
| FERMT2 | Fermitin family homolog 2 | Scaffolding protein, activates integrin |
| FNDC3A | Fibronectin type-III domain-containing protein 3A | Spermatid-Sertoli adhesion in spermatogenesis |
| G3BP2 | Ras GTPase-activating protein-binding protein 2 | Probable scaffold protein, may be involved in mRNA transport |
| GDI2 | Rab GDP dissociation inhibitor beta | Regulates the GDP/GTP exchange reaction of Rab proteins |
| GLYR1 | Putative oxidoreductase GLYR1 | Promotes KDM1B demethylase activity |
| GNPDA1 | Glucosamine-6-phosphate isomerase 1 | Conversion of D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium |
| GOLM1 | Golgi membrane protein 1 | Unknown |
| GPX8 | Probable glutathione peroxidase 8 | Unknown |
| HDDC2 | HD domain-containing protein 2 | Unknown |
| HSD17B10 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Mitochondrial tRNA maturation |
| KIF5B | Kinesin-1 heavy chain | Distribution of mitochondria and lysosomes |
| KPNA2 | Importin subunit alpha-1 | Nuclear protein import |
| KPNB1 | Importin subunit beta-1 | Nuclear protein import |
| LDHB | L-lactate dehydrogenase B chain | Synthesizes lactate from pyruvate |
| LIMCH1 | LIM and calponin homology domains-containing protein 1 | Unknown |
| LPL | Lipoprotein lipase | Hydrolysis of triglycerides of chylomicrons and very low density lipoproteins |
| LRRN1 | Leucine-rich repeat neuronal protein 1 | Unknown |
| MAP4 | Microtubule-associated protein 4 | Promotes microtubule assembly |
| MARS | Methionine–tRNA ligase, cytoplasmic | Ligation of methionine to tRNA molecules |
| MAT2B | Methionine adenosyltransferase 2 subunit beta | Regulatory subunit of S-adenosylmethionine synthetase 2 |
| MPI | Mannose-6-phosphate isomerase | Mannosyl transfer reactions |
| MRPL2 | 39 S ribosomal protein L2, mitochondrial | Component of the 39 S mitochondrial ribosome subunit |
| MYO1D | Unconventional myosin-Id | Intracellular movement |
| MYRIP | Rab effector MyRIP | Melanosome transport |
| NDUFB3 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 | Mitochondrial respiratory chain NADH dehydrogenase |
| NHP2 | H/ACA ribonucleoprotein complex subunit 2 | Ribosome biogenesis |
| NOV | Protein NOV homolog | Cell proliferation, adhesion, differentiation |
| PARK7 | Protein DJ-1 | Oxidative stress and cell death protection |
| PDAP1 | 28 kDa heat- and acid-stable phosphoprotein | PDGFA-stimulated fibroblast growth |
| PLS3 | Plastin-3 | Actin-bundling protein of intestinal microvilli, stereocilia, fibroblast filopodia |
| RABGAP1 | Rab GTPase-activating protein 1 | Unknown |
| RHOT2 | Mitochondrial Rho GTPase 2 | Mitochondrial trafficking |
| RPS13 | 40S ribosomal protein S13 | Component of the ribosomal 40S subunit |
| RTCB | tRNA-splicing ligase RtcB homolog | Subunit of tRNA-splicing ligase |
| SCPEP1 | Retinoid-inducible serine carboxypeptidase | Unknown |
| SEC23B | Protein transport protein Sec. 23B | ER-derived vesicle transport |
| SLC1A5 | Neutral amino acid transporter B(0) | Sodium-dependent amino acid transport |
| SLC7A5 | Large neutral amino acids transporter small subunit 1 | L-leucine transport across the blood-retinal barrier |
| SMARCD1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 | Chromatin remodeling |
| SPR | Sepiapterin reductase | Reduction of pteridine derivatives |
| TKFC | Triokinase/FMN cyclase | Dihydroxyacetone phosphorylation |
| TNKS1BP1 | 182 kDa tankyrase-1-binding protein | Colocalizes with chromosomes in mitosis |
| TPRN | Taperin | Sensory epithelial protein associated with autosomal recessive deafness. |
| TSPAN4 | Tetraspanin-4 | Cell surface glycoprotein binding to integrin |
| TWF2 | Twinfilin-2 | Actin-binding protein involved in motile and morphological processes |
| TXNL1 | Thioredoxin-like protein 1 | Active thioredoxin |
| TYR | Tyrosinase | Formation of pigments, melanin production from tyrosine |
| UBE2O | E2 ubiquitin-conjugating enzyme | Monoubiquitination of target proteins |
| UNC13D | Protein unc-13 homolog D | Vesicle maturation during exocytosis |
| USP5 | Ubiquitin carboxyl-terminal hydrolase 5 | Cleaves multiubiquitin polymers |
| VCL | Vinculin | Actin binding protein involved in cell-matrix adhesion and cell-cell adhesion |
| VPS25 | Vacuolar protein-sorting-associated protein 25 | Sorting of ubiquitinated membrane proteins during endocytosis |
| YAP1 | Transcriptional coactivator YAP1 | Critical regulatory target of the Hippo signaling pathway |