Table 3.
Effect of storage on the expression of some proteins associated with RPE-specific functions. Fold change represents changes in cells stored for three days compared to control cells.
| Gene Symbol | Gene Description | Role in RPE | Fold change | P value (T test) |
|---|---|---|---|---|
| RPE65 | Retinoid isomerohydrolase | Visual pigment regeneration | 1.1 | 0.21 |
| RLBP1 (CRALBP) | Retinaldehyde-binding protein 1 | Visual cycle | 1 | 0.93 |
| TYR | Tyrosinase | Pigmentation | 0.8 | 0.0038 |
| PMEL | Melanocyte protein PMEL | Pigmentation | 1 | 0.65 |
| TYRP1 | 5,6-dihydroxyindole-2-carboxylic acid oxidase | Pigmentation | 0.9 | 0.32 |
| TYRP2 | L-dopachrome tautomerase | Pigmentation | 0.8 | 0.23 |
| MFGE8 | Lactadherin | Phagocytosis | 1 | 0.81 |
| ZO-1 | Tight junction protein ZO-1 | Tight junctions | 1 | 0.90 |
| OCLN | Occludin | Tight junctions | 0.9 | 0.75 |
| KRT18 | Keratin, type I cytoskeletal 18 | Cytoskeleton | 0.9 | 0.08 |