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. 2018 Apr 9;8:5708. doi: 10.1038/s41598-018-23885-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Spearman correlation between metals found in PM and genes indicative of inflammation and cancer. Significant correlations between Ni accumulation and several upregulated genes were observed and are indicated with asterisks. Co and Zn accumulation did not correlate with increased gene expression, whereby the small orange circles in the Co group may be regarded as indices for a weak correlation. The color scale indicates Spearman rho values; strong associations are colored red (rho = 1). The size of the circle also indicates the strength of the correlation, with a larger circle indicating more evidence in support of correlations (rho = 1). Statistical significance is indicated as p < 0.05 (*).