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. 2018 Apr 9;8:5699. doi: 10.1038/s41598-018-23115-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Time-dependent changes in the average peak of intracellular Ca²⁺ influx ([Ca²⁺]_i) after stretch stimulation. The time-dependent changes in the average peak of [Ca²⁺]_i at post-stretch: Wild-type (WT) mice (black) and Clock^Δ19/Δ19 mice (red). The number of analyzed cells is 83, 52, 92, 41, 53, and 57 in the WT mice, and N = 46, 100, 75, 47, 76, and 58 in Clock^Δ19/Δ19 mice from 0 to 20 h. Data are presented as the means ± standard error (SE). The numbers of analyzed cells are indicated in parenthesis below the chart. The abscissa of the each graph is the time axis. 0 h means 12 hours after horse serum shock (HSS). Statistical analyses were done using a one-way analysis of variance (ANOVA) to compare differences among the time points in each group.