Table 2.
Final parameter estimates.
| Parameter | Description | Parameter estimate | Standard error (%CV)a |
|---|---|---|---|
| pbase | Baseline probability of no cure | 1 FIX | — |
| Emax | Maximum achievable probability of cure | 1 FIX | — |
| T50RpZHE/RZME (months)b | The treatment time at which half the Emax is reached for RpZHE and RZME | 2.87 | 5.4 |
| T50RZMH (months)b | The treatment time at which half the Emax is reached for RZMH | 4.35 | 6.0 |
| γ | Shape factor | 9.82 | 23.0 |
Rp = rifapentine, Z = pyrazinamide, M = moxifloxacin, H = isoniazid, E = Ethambutol; CV coefficient of variance; aThe standard errors were calculated using the covariance step in NONMEM; bT50 was significantly different between treatment arms (no statistically significant differences were found in other parameters).