Table 1.

Impact of rs200538373 on ABCA7 exon 41 splicing. This SNP is at position 5, in parenthesis, within intron 41 and is predicted to weaken the splice site, i.e., the prototypic splice donor sequence is CAG/gtragt (exon in upper case, intron in lower case, r = purine).

Exon 41 Splicing	Splice Site Sequence (splice site at ^)	Splicing Score
Normal Splice Site Major G allele	CAG^gtga(g)g	10.07
Normal Splice Site Minor C allele	CAG^gtga(c)gggtgccaggtaggg	7.66
Aberrant Splice Site Extended Exon 41	CAGgtga(g/c)gggtgccag^gtaggg	9.46