Table 1.

Cardiovascular risk parameter evaluation in ApoE^−/−/ICAM-1^+/+ and ApoE^−/−/ICAM-1^−/−mice treated with vehicle or ALDO.

Genotype	ApoE−/−/ICAM-1+/+		ApoE−/−/ICAM-1−/−
Treatment	Vehicle (n)	ALDO (n)	Vehicle (n)	ALDO (n)
Prerandomization
Weight, g	26.3±0.6 (18)	24.7±0.5 (20)	24.8±0.5 (16)	25.5±0.7 (17)
After 4 weeks of infusion
Weight, g	28.6±0.7 (18)	27.6±0.5 (19)	28.9±0.6 (16)	27.5±0.7 (17)
Blood glucose, mg/dL	173±8 (8)	185±7 (8)	170±10 (8)	179±9 (8)
Serum Cholesterol, mg/dL	572±18	535±20	564±25	538±28
Serum ALDO, nmol/L	1.28±0.3	4.07±0.7**	1.32±0.4	4.19±0.3**
Serum Sodium, mEq/L	143.8±0.8	148.2±1*	144.5±1.2	149.0±0.9*
Serum Potassium, mEq/L	3.98±0.2	3.01±0.1*	4.01±0.5	3.09±0.4*
Systolic BP, mm Hg	104±3.5 (6)	111.0±2.7 (6)	106±6.8 (6)	112.9±5.1 (6)
Diastolic BP, mmHg	73±1.7 (6)	79.7±1.3 (6)	73.9±6.2 (6)	79.9±5.2 (6)
Heart Rate, pulse/min	532.9±26.2 (6)	582.4±47.6 (6)	513.7±52 (5)	579.8±35.6 (6)

^*=p<0.05,

^**=p<0.01 ALDO versus Vehicle in the same genotype.