Table 2.
Biomarkers in the Lung cancer, COPD and Control Groups
| Biomarker | Lung Cancer | COPD | Control |
|---|---|---|---|
| N = 20 | N = 27 | N = 13 | |
| Serum, | |||
| Total IgG ng/ml (mean ± SE) | 6.87 ± 0.38** | 5.36 ± 0.39 | 5.97 ± 0.51 |
| Total IgE, ng/ml (median ± IQR) | 243 ± (181.3–305.5)†, ** | 172.5 ± (95.5–297.8)* | 91.0 ± (69.5–266.5) |
| IgG to NTHi OMP, RU (mean ± SE) | 2.10 ± 0.22 | 2.02 ± 0.16 | 1.74 ± 0.24 |
| IgG to NTHi P6, (mean ± SE) | 1.55 ± 0.13 | 1.62 ± 0.10 | 1.32 ± 0.07 |
| Bronchial wash (n (%) | |||
| NTHi Culture positive | 2 (10) | 6 (22) | 1 (8) |
| NTHi PCR positive | 5 (20) | 6 (22) | 2 (15) |
| PPM | |||
| Staphylococcus aureus | 1 | ||
| Streptococcus pneumoniae | 1 | ||
| Pseudomonas aeruginosa | 2 | ||
| Stenotrophomonas maltophilia | 1 | ||
| Non-PPM | |||
| Atypical Mycobacterium | 1 | ||
| Aspergillus fumigatus | 1 | 1 | |
| No microorganism | 17 | 16 | 11 |
*p < 0.05 between COPD and controls; † p < 0.05 between Lung Cancer and controls; ** p < 0.05 between Lung Cancer and COPD
PPM-Potential Pathogenic Organisms