Table 5.
Relationship between risk of death from any cause with low FFMI in COPD cases from COPDGene.
| Covariate | HR (95% CI) | P-value | ||
|---|---|---|---|---|
| Model I | Low FFMIPMA | 1.6(1.2-1.9) | <0.001 | |
| Gender (ref - Male) | 0.82 (0.69-0.97) | 0.017 | ||
| Age (ref 45-55 years) | 55-65 | 1.1 (0.88-1.5) | 0.31 | |
| 65-55 | 1.6 (1.3-2.1) | <0.001 | ||
| >75 | 2.9 (2.2-3.9) | <0.001 | ||
| Race (ref NHW) | 1.2 (0.98-1.5) | 0.08 | ||
| log10(ATS Pack-Years Smoking) | 1.8 (1.3-2.6) | 0.001 | ||
| Final GOLD (ref GOLD=2) | 3 | 1.8 (1.5-2.2) | <0.001 | |
| 4 | 4.8 (4.0-5.8) | <0.001 | ||
| Self-Reported Co-Morbidities | 1-2 | 1.1(0.9-1.3) | 0.31 | |
| 3 or more | 1.5(1.2-1.8) | <0.001 | ||
| Model II | Low Normative FFMIPMA | 1.5 (1.2-1.8) | <0.001 | |
| Gender (ref - Male) | 0.94 (0.81-1.1) | 0.46 | ||
| Age (ref 45-55 years) | 55-65 | 1.1 (0.88-1.5) | 0.32 | |
| 65-55 | 1.7 (1.3-2.2) | <0.001 | ||
| >75 | 3.0 (2.2-4.0) | <0.001 | ||
| Race (ref NHW) | 1.2 (1.0-1.5) | 0.049 | ||
| log10(ATS Pack-Years Smoking) | 1.8 (1.3-2.6) | <0.001 | ||
| Final GOLD (ref GOLD=2) | 3 | 1.8 (1.5-2.1) | <0.001 | |
| 4 | 4.9 (4.1-5.9) | <0.001 | ||
| Self-Reported Co-Morbidities | 1-2 | 1.1(0.91-1.3) | 0.39 | |
| 3 or more | 1.4 (1.2-1.8) | 0.001 | ||
Abbreviations: FFMIPMA- Fat-free mass index derived from pectoralis muscle area, GOLD – Global Initiative for Chronic Lung Disease, ATS – American Thoracic Society.