Fig. 3.

Negative correlations between negative symptoms and brain regions (% signal change averaged across each region) shown to have lower reactivity to the Smoking-Neutral contrast in smokers with schizophrenia. Top: Negative correlations with Scale for the Assessment of Negative Symptoms (SANS) for right anterior (r = −.46, P = .04) and left (r = −.55, P = .01) midline frontal regions. Bottom: Negative correlations were found with Brief Psychiatric Rating Scale (BPRS) negative symptoms (r = −.50 and r = −.57 for right anterior and left midline frontal regions, respectively; P < .02) but not for positive symptoms (P > .50).