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. 2017 Aug 21;44(3):560–574. doi: 10.1093/schbul/sbx109

Table 3.

Regional Cortical Thickness Group Comparisons for Regions Surviving FDR Correction

LH RH
Region ANCOVA a Subgroup M b SD Comparison to HC c d d M b SD Comparison to HC c d d
Banks of superior temporal sulcus LH: F(3, 378) = 5.79, P = .001; RH: F(3, 378) = 3.00, P = .03 CIQ 2.56 .14 =HC −.15 2.65 .14 =HC 0
DIQ 2.50 .20 <HC −.47 2.61 .20 =HC −.24
PIQ 2.51 .17 <HC −.46 2.60 .17 =HC −.33
HC 2.58 .13 — 2.65 .13 —
Caudal anterior cingulate RH: F(3, 378) = 3.40, P = .02 CIQ 2.70 .21 — 2.62 .21 =HC −.17
DIQ 2.66 .20 — 2.58 .20 <HC −.34
PIQ 2.64 .26 — 2.60 .26 =HC −.23
HC 2.68 .26 — 2.66 .26 =HC
Caudal middle frontal LH: F(3, 378) = 9.15, P < .001; RH: F(3, 378) = 5.77, P = .001 CIQ 2.57 .14 <HC −.67e 2.57 .14 <HC −.59e
DIQ 2.59 .10 <HC −.60 2.61 .10 <HC −.35
PIQ 2.59 .09 <HC −.62 2.60 .17 <HC −.33
HC 2.66 .13 — 2.65 .13 —
Entorhinal LH: F(3, 378) = 5.39, P = .001 CIQ 3.26 .34 <HC −.46e 3.43 .34 —
DIQ 3.29 .30 <HC −.40 3.43 .40 —
PIQ 3.32 .34 =HC −.30 3.45 .34 —
HC 3.43 .39 — 3.54 .39 —
Fusiform LH: F(3, 378) = 12.97, P < .001; RH: F(3, 378) = 11.60, P < .001 CIQ 2.60 .14 <HC −.81e 2.60 .14 <HC −.81e
DIQ 2.65 .10 <HC −.52 2.64 .10 <HC −.60
PIQ 2.63 .17 <HC −.62 2.62 .17 <HC −.59
HC 2.71 .13 — 2.71 .13 —
Inferior parietal LH: F(3, 378) = 2.99, P = .03; RH: F(3, 378) = 4.06, P = .007 CIQ 2.58 .14 =HC −.30 2.61 .14 <HC −.37
DIQ 2.59 .10 =HC −.26 2.61 .10 <HC −.43
PIQ 2.59 .17 =HC −.20 2.62 .17 =HC −.26
HC 2.62 .13 — 2.66 .13 —
Inferior temporal LH: F(3, 378) = 12.88, P < .001; RH: F(3, 378) = 10.45, P < .001 CIQ 2.82 .14 <HC −.81e 2.84 .14 <HC −.74
DIQ 2.85 .20 <HC −.69 2.85 .10 <HC −.78
PIQ 2.82 .17 <HC −.73 2.87 .17 <HC −.46
HC 2.93 .13 — 2.94 .13 —
Isthmus cingulate LH: F(3, 378) = 5.79, P = .001 CIQ 2.53 .21 =HC −.23 2.45 .21 —
DIQ 2.52 .20 =HC −.30 2.43 .20 —
PIQ 2.46 .17 <HC −.73 2.44 .17 —
HC 2.57 .13 — 2.49 .13 —
Lateral orbitofrontal LH: F(3, 378) = 17.28, P < .001; RH: F(3, 378) = 15.51, P = .001 CIQ 2.60 .14 <HC −1.11e 2.64 .14 <HC −.89e
DIQ 2.65 .20 <HC −.59 2.67 .20 <HC −.53
PIQ 2.64 .17 <HC −.73 2.65 .17 <HC −.73
HC 2.75 .13 — 2.76 .13 —
Lingual RH: F(3, 378) = 3.14, P = .03 CIQ 1.98 .14 — 2.02 .14 =HC −.37
DIQ 1.99 .10 — 2.05 .10 =HC −.17
PIQ 1.98 .09 — 2.03 .09 =HC −.66
HC 2.01 .13 — 2.07 .13 =HC
Medial orbitofrontal LH: F(3, 378) = 9.52, P < .001; RH: F(3, 378) = 11.50, P < .001 CIQ 2.53 .14 <HC −.96e 2.50 .14 <HC −.89e
DIQ 2.59 .20 <HC −.42 2.55 .20 <HC −.42
PIQ 2.58 .17 <HC −.53 2.53 .17 <HC −.59
HC 2.66 .13 — 2.62 .13 —
Middle temporal LH: F(3, 378) = 13.14, P < .001 CIQ 2.92 .14 <HC −.67 2.95 .14 <HC −.74
DIQ 2.91 .10 <HC −.86 2.96 .10 <HC −.77
PIQ 2.90 .17 <HC −.73 2.98 .17 <HC −.46
HC 3.01 .13 — 3.05 .13 —
Parahippocampal LH: F(3, 378) = 7.71, P < .001 RH: F(3, 378) = 11.21, P < .001 CIQ 2.46 .34 <HC and DIQ and PIQ −.83e 2.53 .27 <HC −.49e
DIQ 2.61 .30 <HC −.36 2.59 .30 =HC −.25
PIQ 2.64 .34 =HC −.23 2.60 .26 =HC −.23
HC 2.71 .26 — 2.66 .26 —
Pars opercularis LH: F(3, 378) = 6.42, P < .001; RH: F(3, 378) = 13.80, P < .001 CIQ 2.58 .14 <HC −.59e 2.59 .14 <HC −.34e
DIQ 2.60 .10 <HC −.52 2.61 .10 <HC −.25
PIQ 2.59 .17 <HC −.46 2.60 .17 <HC −.27
HC 2.66 .13 — 2.70 .13 —
Pars orbitalis LH: F(3, 378) = 13.81, P < .001 RH: F(3, 378) = 7.90, P < .001 CIQ 2.74 .21 <HC −.59 2.78 .21 <HC −.51e
DIQ 2.77 .20 <HC −.47 2.81 .20 <HC −.39
PIQ 2.73 .17 <HC −.68 2.80 .17 <HC −.46
HC 2.88 .26 — 2.90 .26 —
Pars triangularis LH: F(3, 378) = 8.72, P < .001 RH: F(3, 378) = 8.76, P < .001 CIQ 2.53 .14 <HC −.59e 2.55 .14 <HC −.59
DIQ 2.52 .20 <HC −.53 2.57 .10 <HC −.52
PIQ 2.53 .17 <HC −.53 2.54 .17 <HC −.59
HC 2.61 .13 — 2.63 .13 —
Posterior cingulate LH: F(3, 378) = 3.41, P = .02 CIQ 2.57 .14 =HC −.37e 2.53 .14 —
DIQ 2.57 .20 =HC −.30 2.53 .10 —
PIQ 2.57 .17 =HC −.33 2.54 .17 —
HC 2.62 .13 — 2.56 .13 —
Precentral LH: F(3, 378) = 4.28, P = .005; RH: F(3, 378) = 4.88, P = .002 CIQ 2.46 .14 <HC −.44e 2.45 .14 <HC −.52e
DIQ 2.47 .10 <HC −.43 2.47 .10 <HC −.43
PIQ 2.47 .17 <HC −.33 2.47 .17 <HC −.33
HC 2.52 .13 — 2.52 .13 —
Precuneus LH: F(3, 378) = 3.67, P = .01 CIQ 2.41 .14 =HC −.44e 2.41 .14 —
DIQ 2.43 .10 <HC −.34 2.43 .10 —
PIQ 2.46 .09 =HC −.09 2.45 .09 —
HC 2.47 .13 — 2.46 .13 —
Rostral anterior cingulate LH: F(3, 378) = 6.65, P < .001 CIQ 2.83 .21 <HC and DIQ and PIQ −.68e 2.96 .21 —
DIQ 2.92 .20 <HC −.30 2.97 .20 —
PIQ 2.92 .26 <HC −.27 3.01 .17 —
HC 2.99 .26 — 3.02 .26 —
Rostral middle frontal LH: F(3, 378) = 7.36, P < .001; RH: F(3, 378) = 7.42, P < .001 CIQ 2.47 .14 <HC −.59 2.48 .14 <HC −.59e
DIQ 2.50 .10 <HC −.43 2.52 .10 <HC −.34
PIQ 2.48 .09 <HC −.63 2.50 .09 <HC −.54
HC 2.55 .13 — 2.56 .13 —
Superior frontal LH: F(3, 378) = 5.86, P < .001; RH: F(3, 378) = 9.44, P < .001 CIQ 2.77 .14 <HC −.74e 2.76 .14 <HC −.81e
DIQ 2.82 .10 <HC −.43 2.81 .10 <HC −.52
PIQ 2.81 .17 <HC −.40 2.80 .17 <HC −.46
HC 2.87 .13 — 2.87 .13 —
Superior temporal LH: F(3, 378) = 8.97, P < .001; RH: F(3, 378) = 14.82, P < .001 CIQ 2.77 .14 <HC −.59 2.79 .14 <HC −.81e
DIQ 2.78 .10 <HC −.60 2.82 .10 <HC −.69
PIQ 2.76 .17 <HC −.59 2.80 .17 <HC −.66
HC 2.85 .13 — 2.90 .13 —
Supramarginal LH: F(3, 378) = 3.65, P = .01 RH: F(3, 378) = 7.06 P <.001 CIQ 2.61 .14 <HC −.52e 2.61 .14 <HC −.59e
DIQ 2.64 .10 =HC −.34 2.63 .10 <HC −.52
PIQ 2.65 .17 =HC −.20 2.63 .17 <HC −.40
HC 2.68 .13 — 2.69 .13 —
Frontal pole RH: F(3, 378) = 4.56, P = .004 CIQ 2.90 .27 — 2.84 .27 <HC −.42
DIQ 2.96 .30 — 2.87 .30 =HC −.28
PIQ 2.88 .26 — 2.83 .26 <HC −.46
HC 2.96 .26 — 2.95 .26
Temporal pole LH: F(3, 378) = 5.28, P = .001; RH: F(3, 378) = 7.85, P < .001 CIQ 3.55 .34 <HC −.52 3.66e .34 <HC and DIQ −.73e
DIQ 3.68 .30 <HC −.17 3.79 .30 <HC −.32
PIQ 3.61 .34 <HC −.36 3.74 .34 <HC −.46
HC 3.74 .39 — 3.88 .26 —
Transverse temporal RH: F(3, 378) = 4.33, P = .005 CIQ 2.41 .21 — −.13 2.43 .21 =HC −.25
DIQ 2.38 .20 — −.26 2.42 .20 <HC −.30
PIQ 2.38 .17 — −.27 2.39 .17 <HC .46
HC 2.44 .26 — 2.49 .26 —
Insula LH: F(3, 378) = 12.28, P < .001; RH: F(3, 378) = 8.86, P < .001 CIQ 3.03 .14 <HC −.74 3.00 .21 <HC −.57
DIQ 3.06 .20 <HC −.42 3.02 .20 <HC −.47
PIQ 3.02 .17 <HC −.73 3.00 .17 <HC −.66
HC 3.13 .13 — 3.10 .13 —

Note: CIQ, compromised patients; DIQ, deteriorated schizophrenia patients; PIQ, putatively preserved schizophrenia patients; LH, left hemisphere; RH, right hemisphere.

aAll Ps thresholded at a false discovery rate of 5%.

bAll values are adjusted for age, gender, site.

cIf a comparison is not reported, it did not survive post hoc comparison correction. =HC (healthy controls) implies no significant difference to HCs; <HC implies significant reductions relative to HCs.

d d = Cohen’s d effect sizes for patient–control comparisons.

eRepresents qualitatively larger control–patient effect sizes in compromised patients.