. 2016 Nov 4;24(5-6):136–147. doi: 10.1177/2040206616671571

Table 4.

Sensitivity to MDL-860 in plaque inhibition tests of virus brain isolates from newborn mice infected with CVB1.

Group	MDL-860 IC₅₀ values (μM) of viral brain samples
	Taken on day (after viral inoculation)
	4	5	6	7	8	9	10	11	12	13
Placebo	3.372	2.843	^a	^a	^a	^a	^a	^a	^a	^a
MDL-860 75 mg/kg	2.057	2.582	8.206	>10.0	^a	^a	^a	^a	^a	^a
P₂₅M₇₅O₂₅ consecutive	2.165	2.388	1.418	0.346	0.319	0.173	0.153	0.313	0.316	0.318^###
P₂₅M₇₅O₂₅ simultaneous	1.894	2.477	^a	^a	^a	^a	^a	^a	^a	^a

After day 5(7), no animals were alive, 100% mortality rate. Statistical analysis was performed with one-way ANOVA (Bonferroni’s multiple comparison post-test).

^###

P < 0.001 vs. PMO consecutive day 5