Figure 4.

Predicted structure of ZIKV NS2B–NS3 complex. (a) The full-length ZIKV NS3 homology model with indicated protease and helicase domains. The homology model of the DENV NS2B–NS3 protein was built with the MVEV template (PDBID 2WV9). Dark regions are structurally conserved residues between the model and the MVEV template while white residues are dissimilar. Highlighted are residues that are dissimilar between the African and Asian strains of ZIKV. (b) Comparison of the ZIKV NS3 protease homology model to a DENV-2 NS3 protease crystal structure (PDBID 3U1I) bound to peptidomimetic inhibitor (colored as element). Catalytic residues are indicated and identical binding pocket residues are colored as dark surface.