Table II. Patients included: characteristics.

Identifier	Age (y)	Gender	Smoking	Histology	Computerized Tomography Scan Appearance	Tumor Size (cm)	Stage	Molecular Classification (KRAS or EGFR mutations)	CT37 RT-PCR Log2	CT37 IHC
NSCLC_1	64	Female	Current <1 pack/d	ADC	Solitary part-solid GGN; solid portion 0.4 cm	1.6	T1aN0M0	EGFR exon 21 L858R	6.0	Negative
NSCLC_2	69	Male	Current >1 pack/d	Favoring ADC	Three solid GGN in the same lobe; the larger invasive to the main carina with metastasis to ipsilateral subcarinal lymph nodes	2.8, 1, and 0.8	T4N2M0	KRAS exon 2 codon 12 35G > A; G12AD	6.10	Low (+)
NSCLC_3	56	Male	Former <1 pack/d	ADC	Solitary solid GGN; the visceral pleura was minimally compromised	3.2	T2aN0M0	EGFR exon 19 in-frame Deletion of ΔE746-A750	5.93	Negative
NSCLC_4	61	Male	Current <1 pack/d	ADC	Solitary solid GGN	2	T1aN0M0	EGFR exon 21 L858R	5.88	Negative
NSCLC_5	70	Male	Former <1 pack/d	ADC	Solitary solid GGN	1.6	T1aN0M0	Not found	6.15	Low (+)
NSCLC_6	68	Male	Former >1 pack/d	Favoring ADC	Presence of two solid nodules in the same lobe with metastasis to ipsilateral hilar lymph nodes	5 and 1.5	T3N1M0	KRAS exon 2 codon 12 35G > A; G12D	6.11	Negative
NSCLC_7	58	Male	Former <1 pack/d	ADC	Solitary solid GGN	2.8	T1bN0M0	EGFR exon 21 L858R	6.27	Moderate (++)
NSCLC_8	63	Female	Former >1 pack/d	ADC	Solitary solid GGN	3	T1bN0M0	Not found	5.81	Negative
NSCLC_9	59	Female	Former <1 pack/d	ADC	Solitary solid GGN	2.2	T1aN0M0	EGFR exon 19 in-frame Deletion of ΔE746-A750	5.97	Low (+)

A semiquantitative scoring with + or − signs was used. −, no staining; +, <10% of neoplastic cells staining (low staining); ++, 10–50% of neoplastic cells staining (moderate staining); +++, >50% of neoplastic cells staining (high staining). GGN, ground-glass nodule; KRAS, K-Ras protein 21 (p21) oncogene.