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Therapeutic effect of rFc multimers in experimental ITP. Dose escalation of anti-platelet Ab (MWReg30) maintains platelet nadir over time. Treatment with a single i.p. dose of Fc-μTP-L309C at day 2 results in alleviation of ITP comparable with IVIG. Shown are the mean platelet values in the blood; data show the mean (± SEM) of platelet counts (Fc-μTP-L309C, n = 5; IVIG and PBS, n = 3).
