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. 2018 Mar 12;200(8):2542–2553. doi: 10.4049/jimmunol.1701171

FIGURE 8.

FIGURE 8.

Effect of Fc-μTP-L309C on Fc receptor expression and function. (A) Induction of calcium flux in human granulocytes (n = 4 experiments) and monocytes (n = 2 experiments). HAGG served as positive control; one representative experiment is shown. (B) Fc-μTP-L309C fails to activate the respiratory burst in human granulocytes (n = 4 experiments) and monocytes (n = 2 experiments); one representative experiment is shown. (C) Calcium flux in human granulocytes induced by HAGG is inhibited by Fc-μTP-L309C; one representative of four experiments is shown. (B and C) Mean ± SD of duplicates are shown. (D) Fc-μTP-L309C inhibits the activation of the respiratory burst in response to IgG-coated rabbit RBCs in human granulocytes. (B and D) Left and right columns are 1.5 and 0.4 mg/ml doses, respectively. (E) Inhibition of ADCC of anti-D–treated O+ human RBCs by Fc-μTP-L309C (mean ± SEM, n = 3). (F) Inhibition of phagocytosis of IgG-coated FITC-labeled latex beads by THP1 cells. Fc Block was used as control (mean ± SEM, n = 3).