Table 2.
Initial staging, treatment, and outcome for 26 reported cases of primary ductal adenocarcinoma
| Literature | Initial staging | Treatment | Metastasis | Outcome |
|---|---|---|---|---|
| Our case 1 | T4N0M0 | Exenteration, RT and CT | Nil | AOD at 2.25 years |
| Our case 2 | T4N0M0 | Exenteration with bone removal, RT, and CT | Right neck LN, lung | AWD at 1.75 years |
| Andreasen et al. 2017[9] | T4bN0M0 | Exenteration and RT | Nil | DO at 1.6 years |
| T1N0M1 | Nil | Lung, liver, suprarenal glands, vertebral column, cerebellum; LN of the neck, thorax, abdomen, and thorax | DWD at 5 years | |
| T4bN0M0 | Tumor excision and RT | Disseminated disease | DWD at 1.4 years | |
| Dennie, 2015[7] | T4cN0M0 | Exenteration, RT, and target therapy | Chest and thorax spine, cerebellum, lung | DWD at 4 years |
| Lau et al. 2015[8] | T2N0M0 | Tumor excision | Nil | AOD at 0.17 years |
| Zhu et al. 2015[3] | T1N0M0 | Exenteration and RT | Nil | AOD at 0.75 years |
| Ricci et al. 2014[5] | T2NxM1 | Exenteration, RT, and total androgen blockade | L1 spine | AWD at 1.6 years |
| Min et al. 2014[6] | T4bN0M0 | Orbital mass removal and RT | Nil | AOD at 0.4 years |
| Kubota et al. 2013[11] | T4bN1M0 | RT to ocular adnexa and surgical resection of submandibular LN | Cervical LN, lung | DWD at 2 years |
| T2N0M0 | Exenteration with bone removal | Submandibular LN, bone, and liver | DWD at 1.3 years | |
| T4aN0M0 | Exenteration and RT | Spine, brain, liver | DWD at 4.3 years | |
| T4bN0M0 | Exenteration with bone removal and RT | Lung, brain | AWD at 10 years | |
| T2N0M0 | Complete tumor resection with globe-sparing surgery | Nil | AOD at 5.5 years | |
| Damasceno and Holbach, 2012[12] | T2N0M0 | Exenteration | Ipsilateral parotid and cervical LN | DWD at 2 years |
| Giliberti et al. 2011[10] | T4cN0M0 | Exenteration | Nil | AOD at 0.5 years |
| Ishida et al. 2009[13] | T2NxMx | Tumor resection twice for recurrence and RT | NA | AWD at 0.7 years |
| Lee and Oh, 2009[14] | T2N0M0 | Tumor resection (en bloc) with globe-sparing surgery | NA | AOD at 0.8 years |
| Kim et al. 2008[15] | NA | Exenteration, RT, and CT | Chest skin, lymphatics, ilium, rib, femur, spine, orbit, postnasal region, Lspine, cerebellum | DWD at 17 years |
| Takahira et al. 2007[4] | T2N0M0 | Total tumor excision and RT | Nil | NA |
| Milman et al. 2005[16] | T1N1M1 | Exenteration and RT | Parotid, cervical LN | AWD at 0.5 years |
| Kurisu et al. 2005[17] | T2N0M0 | En bloc tumor resection and RT | Local recurrence; brain, lungs, liver, pancreas, common bile duct | DWD at 2.8 years |
| Krishnakumar et al. 2003[18] | NA | Exenteration and RT | Nil | AOD at 1.6 years |
| Paulino and Huvos, 1999[19] | Parotid | Exenteration and RT | Neck LN | AOD at 6 years |
| Nasu et al. 1998[20] | T2NxMx | En bloc tumor resection with frontal craniotomy and RT | Sella turcica to the subdural spaces of the right temporal lobe | AOD at 2 years |
| Katz et al. 1996[2] | T4aN0M0 | Frontotemporal craniotomy, en bloc orbitectomy, and RT | Nil | AOD at 0.8 years |
AOD=Alive without disease, AWD=Alive with disease, CT=Chemotherapy, DO=Died of other cause, DWD=Died with disease, LN=Lymph node, NA=Not available, Nil=No evidence of metastasis, RT=Radiotherapy