Figure 2. Change in distance walked after 5 days of treatment with elamipretide.

The p value is the comparison of the high-dose arms with placebo for the heterogeneous slope model. Change in distance walked after 5 days of treatment with elamipretide is represented. There is a clear upward dose response between the distance walked and the dose escalation in the treatment arms. In a backward elimination model to adjust for additional possible confounders (sex and the baseline distance walked–by–treatment interaction), the difference in distance walked (at the average value of baseline distance walked in the study of ≈380 m) was a 3.0-m increase for the placebo-treated participants compared to 51.2 m for the highest-dose group (p = 0.0297).