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. 2018 Jan 22;77(4):612–619. doi: 10.1136/annrheumdis-2017-212401

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Inflammatory signature in patients with SIFD. (A) Serum cytokine and chemokine levels from patient 4 compared with paediatric healthy controls. For patient 4, each symbol represents measurements of serum samples collected during two independent flares (CRP levels 133 mg/L and 220 mg/L, respectively, normal values <3 mg/L). Forty-eight cytokines were measured by bead-based immunoassay as described in Material and Methods. Proinflammatory cytokines IL-6, IL-12p40, IL-18, IFN-γ and IFN-induced chemokines (IP10 and MIG) and levels of circulating soluble TNF-R1 (sTNF-R1) and TNF-R2 (sTNF-R2) were at least 10 SD higher in the patient compared with the average concentration of the 11 healthy controls. (B) Elevated levels of cytokines and chemokines, as shown for P4 in panel A, in postmortem plasma sample from patient 3 and a healthy control.