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. 2018 Feb 7;77(4):620–623. doi: 10.1136/annrheumdis-2017-211848

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Association of variants at GLIS3 with osteoarthritis. The x-axis shows the genomic interval, the left y-axis shows the statistical significance of association as negative log10 of P values. rs10116772 was used as the reference SNP and its P value in the discovery set, and postreplication is denoted by the purple circle and diamond, respectively. The linkage disequilibrium is presented as pairwise r² between the reference SNP and the other SNPs in the region with colours according to different bins (0–0.2: dark blue; 0.2–0.4: light blue; 0.4–0.6: green; 0.6–0.8: orange; 0.8–1.0: red). The location of variants associated with other traits as reported in the NHGRI-EBI GWAS catalogue (P<10⁻⁵) is shown by the arrows. SNP, single nucleotide polymorphism.