Table 1.

Summary statistics of rs10116772 in the discovery and replication studies

Study	Stratum	n (case/control)	EA	EAF	P value	OR (95% CI)
Discovery	Knee and/or hip OA TJR versus controls	5410/9936	A	0.40	3.29×10–6	0.97 (0.96 to 0.98)
Replication	Knee and/or hip OA operation versus non-OA controls	17 894/89 470	A	0.40	2.32×10–3	0.96 (0.94 to 0.99)
Meta-analysis		23 304/99 406	A	0.40	3.71×10–8	0.97 (0.96 to 0.98)

EA, effect allele; EAF, effect allele frequency; TJR, total joint replacement.