Table 1.
Diagnostic performance of the gamma-glutamyl transpeptidase to platelet ratio (GPR), aspartate aminotransferase to platelet ratio index (APRI), and fibrosis index based on four factors (FIB-4) in a Chinese population with chronic hepatitis B virus (HBV) infection
| GPR | F0–1 versus F2–4 | F0–2 versus F3–4 | F0–3 versus F4 | |||
| AUROC (95% CI) | 0.67 (0.64 to 0.70) | 0.70 (0.67 to 0.72) | 0.71 (0.68 to 0.73) | |||
| Cut-off values* | 0.32 | 0.32 | 0.56 | |||
| Sensitivity/specificity (%) | 40/78 | 47/79 | 36/85 | |||
| Correctly classified (%) | 49 | 61 | 72 | |||
| PPV/NPV (%) | 85/30 | 72/55 | 46/78 | |||
| Positive/negative LR | 1.8/0.8 | 2.2/0.7 | 2.3/0.8 | |||
| APRI | ||||||
| AUROC (95% CI) | 0.68 (0.65 to 0.71) | 0.70 (0.67 to 0.73) | 0.66 (0.63 to 0.69) | |||
| Cut-off values† | 0.5 | 1.5 | 1.0 | 2.0 | ||
| Sensitivity/specificity (%) | 69/59 | 30/87 | 51/70 | 28/82 | ||
| Correctly classified (%) | 67 | 44 | 65 | 68 | ||
| PPV/NPV (%) | 84/38 | 88/29 | 38/79 | 37/76 | ||
| Positive/negative LR | 1.7/0.5 | 2.4/0.8 | 1.7/0.7 | 1.6/0.9 | ||
| Indeterminate results (%) | 37 | 15 | ||||
| FIB-4 | ||||||
| AUROC (95% CI) | 0.73 (0.70 to 0.76) | 0.76 (0.74 to 0.79) | 0.77 (0.75 to 0.80) | |||
| Cut-off values‡ | 1.45 | 3.25 | ||||
| Sensitivity/specificity (%) | 64/74 | 26/93 | ||||
| Correctly classified (%) | 69 | 56 | ||||
| PPV/NPV (%) | 75/63 | 82/51 | ||||
| Positive/negative LR | 2.5/0.5 | 3.9/0.8 | ||||
| Indeterminate results (%) | 30 | |||||
| Comparison of AUROCs | ||||||
| GPR versus APRI | p=0.473 | p=0.768 | p<0.001 | |||
| GPR versus FIB-4 | p<0.001 | p<0.001 | p<0.001 | |||
*Predetermined cut-off values of GPR were used (0.32 to distinguish significant fibrosis, 0.32 to distinguish extensive fibrosis and 0.56 to distinguish cirrhosis).
†Predetermined cut-off values of APRI were used (0.5 and 1.5 to distinguish significant fibrosis, and 1.0 and 2.0 to distinguish cirrhosis).
‡Predetermined cut-off values of FIB-4 were used (1.45 and 3.25 to distinguish extensive fibrosis).
APRI, aspartate aminotransferase to platelet ratio index; AUROC, area under the receiver operating characteristic curve; FIB-4, fibrosis index based on four factors; GPR, gamma-glutamyl transpeptidase to platelet ratio; HBV, hepatitis B virus; LR, likelihood ratio; NPV, negative predictive value; PPV, positive predictive value.