Table 4.
Per pathogen microbiological response
| By pathogen objective responders at 48–72 h, ME at 48–72 h analysis set |
Per pathogen microbiological response (documented or presumed eradication),a ME at FU analysis set |
|||
|---|---|---|---|---|
| delafloxacin, N = 220 | vancomycin + aztreonam, N = 225 | delafloxacin, N = 179 | vancomycin + aztreonam, N = 184 | |
| S. aureus | 123/145 (84.8%) | 134/150 (89.3%) | 115/117 (98.3%) | 119/121 (98.3%) |
| MRSA | 59/72 (81.9%) | 76/84 (90.5%) | 58/58 (100%) | 65/66 (98.5%) |
| MSSA | 65/74 (87.8%) | 58/66 (87.9%) | 57/59 (96.6%) | 54/55 (98.2%) |
| Streptococcus anginosus groupb | 28/30 (93.3%) | 33/37 (89.2%) | 22/22 (100%) | 26/27 (96.3%) |
| Staphylococcus epidermidis | 16/18 (88.9%) | 13/15 (86.7%) | 13/14 (92.9%) | 14/14 (100%) |
| Klebsiella pneumoniae | 10/11 (90.9%) | 9/10 (90%) | 9/9 (100%) | 9/9 (100%) |
| Escherichia coli | 3/5 (60%) | 9/9 (100%) | 4/4 (100%) | 7/7 (100%) |
| Streptococcus pyogenes | 5/7 (71.4%) | 2/5 (40%) | 5/5 (100%) | 4/4 (100%) |
| Staphylococcus lugdunensis | 6/7 (85.7%) | 3/3 (100%) | 7/7 (100%) | 1/1 (100%) |
| Staphylococcus haemolyticus | 5/5 (100%) | 2/2 (100%) | 5/5 (100%) | 2/2 (100%) |
a
Investigator-assessed response in ME at FU analysis set was the same as per pathogen microbiological response.
b
S. anginosus group includes S. anginosus, Streptococcus intermedius and Streptococcus constellatus.