Table 1.
Susceptibility of LR-CoNS (n = 168) to last-resort antimicrobial families (glycopeptides, daptomycin, fifth-generation cephalosporins and oxazolidinones)
| Antimicrobial class | Agent | MIC range (mg/L) | MIC50 (mg/L) | MIC90 (mg/L) | EUCAST MIC breakpoint (mg/L) |
|---|---|---|---|---|---|
| Glycopeptides | vancomycin | 0.75–4 | 1.5 | 2 | 4 |
| teicoplanin | 0.5–6 | 2.5 | 4 | 4 | |
| Lipopeptide | daptomycin | 0.12–1 | 0.25 | 0.5 | 1 |
| β-Lactams | ceftobiprole | 0.12–1 | 0.75 | 1 | 2 |
| ceftaroline | 0.06–0.5 | 0.25 | 0.5 | 1 | |
| Oxazolidinones | linezolid | 6 to >256 | 128 | 256 | 4 |
| tedizolid | 2 to >32 | 8 | 32 | 0.5 |