Inhibitory effects of compounds 2a–2i against CDK2/cyclin A and CDK9/cyclin T1.
| ||||
|---|---|---|---|---|
| Compd. | R1 | R2 | IC50a (μM) | |
| CDK2/cyclin A | CDK9/cyclin T1 | |||
| 1 |
|
F | 1.71 | 0.78b |
| 2a |
|
F | 0.32 ± 0.28 | 0.30 ± 0.01 |
| 2b |
|
F | 0.78 ± 0.04 | 0.39 ± 0.08 |
| 2c |
|
F | 0.91 ± 0.11 | 1.10 ± 0.02 |
| 2d |
|
F | 0.94 ± 0.43 | 0.32 ± 0.05 |
| 2e |
|
F | 0.24 ± 0.04 | 0.095 ± 0.004 |
| 2f |
|
F | 1.60 ± 0.11 | 0.57 ± 0.12 |
| 2g |
|
F | 0.57 ± 0.05 | 0.49 ± 0.27 |
| 2h |
|
F | 5.60 ± 0.53 | 2.20 ± 0.32 |
| 2i |
|
NO2 | 0.78 ± 0.12 | 0.48 ± 0.08 |
a
The IC50 value was interpolated from dose–response data with six different concentrations. Each test was performed in duplicate. Data represent the average of duplicate measurements.
b
The data were cited from ref. 16.