Inhibitory activities of selected compounds against tumor cell lines by the SRB assay.
| Compd. | GI50a (μM) | ||||
|---|---|---|---|---|---|
| MDA-MB-231 | MCF-7 | A549 | KB | KB-vinb | |
| 1 | — | — | 1.18 ± 0.13 | 1.26 ± 0.05 | 1.81 ± 0.60 |
| 2a | 1.20 ± 0.06 | 0.67 ± 0.06 | 0.72 ± 0.01 | 0.57 ± 0.01 | 2.54 ± 0.01 |
| 2b | 5.80 ± 0.08 | 3.80 ± 0.24 | 2.33 ± 0.03 | 2.20 ± 0.37 | 5.99 ± 0.26 |
| 2c | 6.77 ± 0.38 | 3.94 ± 0.31 | 2.12 ± 0.26 | 2.03 ± 0.32 | 3.90 ± 0.07 |
| 2d | 1.64 ± 0.15 | 2.83 ± 0.03 | 1.89 ± 0.19 | 3.08 ± 0.16 | 3.20 ± 0.18 |
| 2e | 3.98 ± 0.16 | 4.49 ± 0.03 | 1.31 ± 0.07 | 4.78 ± 0.38 | 2.54 ± 0.26 |
| 2f | 12.99 ± 0.38 | 6.02 ± 0.51 | 3.47 ± 0.44 | 7.04 ± 0.08 | 4.54 ± 0.04 |
| 2g | 4.64 ± 0.06 | 0.67 ± 0.03 | 0.71 ± 0.06 | 0.56 ± 0.08 | 1.66 ± 0.16 |
| 2h | >10c | >10 | >10 | >10 | >10 |
| 2i | 5.94 ± 0.33 | 10.23 ± 0.03 | 4.90 ± 0.45 | 5.73 ± 0.35 | 5.98 ± 0.24 |
| 3a | >10 | 5.97 ± 0.19 | 0.72 ± 0.04 | 0.59 ± 0.05 | 1.66 ± 0.16 |
| 3b | 2.07 ± 0.12 | 2.73 ± 0.48 | 1.31 ± 0.18 | 3.27 ± 0.13 | 2.36 ± 0.33 |
| 3c | 3.24 ± 0.05 | 2.65 ± 0.40 | 1.20 ± 0.05 | 2.31 ± 0.11 | 6.34 ± 0.54 |
| 3d | 3.30 ± 0.23 | 6.16 ± 0.14 | 1.09 ± 0.03 | 2.60 ± 0.45 | 7.11 ± 0.23 |
| 3e | 5.42 ± 0.35 | 6.73 ± 0.23 | 0.72 ± 0.01 | 3.82 ± 0.11 | 11.64 ± 0.04 |
| 3g | 5.51 ± 0.16 | 3.98 ± 0.26 | 0.69 ± 0.002 | 3.89 ± 0.06 | 0.98 ± 0.13 |
| 3i | 4.05 ± 0.14 | 1.88 ± 0.12 | 0.70 ± 0.002 | 2.87 ± 0.24 | 1.09 ± 0.06 |
| 3j | 5.31 ± 0.19 | 2.37 ± 0.62 | 1.15 ± 0.08 | 0.60 ± 0.04 | 0.88 ± 0.01 |
| 3k | 6.01 ± 0.08 | 4.48 ± 0.39 | 3.04 ± 0.18 | 3.80 ± 0.34 | 4.52 ± 0.01 |
| 3m | 2.84 ± 0.67 | 7.76 ± 0.52 | 1.25 ± 0.08 | 0.40 ± 0.09 | 3.70 ± 0.53 |
| 3n | 4.77 ± 0.27 | 7.16 ± 0.54 | 0.71 ± 0.01 | 4.44 ± 0.42 | 0.95 ± 0.001 |
| 3o | 7.00 ± 0.06 | 3.75 ± 0.28 | 0.85 ± 0.01 | 0.98 ± 0.05 | 0.84 ± 0.02 |
| FVPd | — | — | 0.14 ± 0.01 | 0.16 ± 0.01 | 0.18 ± 0.01 |
| Paclitaxel (nM) | 7.76 ± 0.39 | 8.78 ± 0.79 | 5.98 ± 0.40 | 4.94 ± 0.21 | 1518.36 ± 141.54 |
a
The GI50 values are expressed as means ± SD (standard deviation) of three independent measurements.
b
Cell lines: MDA-MB-231 (human breast carcinoma cell line), MCF-7 (Michigan Cancer Foundation-7), A549 (lung cancer), KB (nasopharyngeal carcinoma) and KB-vin (vincristine-resistant KB subline).
c
No significant inhibition against tumor cell growth was observed under the concentration of 10 μM.
d
The data were cited from ref. 16.