Figure 1.
Schematic diagram of the semi-mechanistic model describing the pharmacokinetics of moxifloxacin in patients with drug-susceptible recurrent TB. Tlag, absorption lag time; Fpre-H, pre-hepatic bioavailability; Ka, absorption rate constant; EH, hepatic extraction; CLint, (hepatic) clearance intrinsic; fu, free (unbound) fraction of drug in plasma; QH, hepatic plasma flow; CLH, hepatic clearance; VC, volume of central compartment; VP, volume of peripheral compartment; Q, inter-compartmental clearance; QH, hepatic plasma flow.