Figure 3.

Model-based moxifloxacin exposure stratified by co-administration of rifampicin and/or efavirenz. The left panel shows AUC_0–∞ (for steady-state dosing) or AUC_0–24 (for single dose), while the right panel shows C_max. The dots are the model-predicted individual exposures observed in the study cohort and based on empirical Bayes estimates; geometric means were used to summarize multiple values from the same subject. The box summarizes the median and IQR, while the whiskers are the 2.5%–97.5% range. SS, steady-state; SD, single dose; MXF, moxifloxacin; RIF, rifampicin; EFV, efavirenz.