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. 2017 Jun 1;72(8):2320–2325. doi: 10.1093/jac/dkx152

Figure 1.

Figure 1

Biapenem activity in the mouse models of acute TB. (a) M. tuberculosis H37Rv cfu in the lungs of mice after 4 weeks of treatment with isoniazid (INH), rifampicin (RIF) or biapenem (BIA). The dose (in mg/kg) and rhythm (q24h or q12h) of administration is written after each drug abbreviation. Treatment was initiated 3 days after infection, and the broken horizontal line represents the lung cfu count at the start of treatment. Each data point represents lung cfu counts from one mouse, and error bars represent standard deviation of the mean. Gross pathology images of all mouse lungs from this experiment are presented in Figure S1. (b) M. tuberculosis H37Rv cfu in the lungs of mice after 4 weeks of treatment with isoniazid, rifampicin or biapenem in a late-phase acute model of mouse TB in which treatment is initiated 2 weeks after infection. The broken vertical line represents the day of starting treatment; each data point represents the mean and the error bars represent the standard deviation (five mice per group per time point).