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. 2016 Dec 15;72(3):691–695. doi: 10.1093/jac/dkw477

Table 2.

AMR and virulence genes present in four mcr-1-positive isolates from WGS

Isolate and origin Inc-types present Estimated size of mcr-1-containing plasmid (kb)a Similarity to pHNSHP45 (%) Maximum similarity to publicly available mcr-1 plasmids (%) Colistin resistance genes Other AMR genes Virulence genes

  • Clinical isolatec

  • O149:H10

  • 2015 veterinary submission

 Inc1, IncX4, IncFII(pCoo), IncFIB(AP001918), IncFIC(FII), IncY 32.7 28 99 phoPb, phoQb, pmrAb, etkb, mcr-1 aadA1b, ant3-Ia, dfrA1, folPb, sul2 aec15-19, aec22-27, aec29-32, astA9, cah, eaeH, ecpA-E, ecpR, ehaB, eltA-B, espL4, espR1, faeC-E, faeG-J, fimF-G, hlyA-E, ibeB-C, ItcA, stb1, shf

  • PO155c

  • –:H56

  • 2015 surveillance study

 Incl1, Col8282, pO111, IncX1 91.2 19 90 mcr-1 aac3-IVa, aadA2, ant3-Ia, aph3-Ib, aph4-Ia, aph6-Id, blaTEM-1, cml, dfrA12, inuF, sul2, tetA aec19, aec32, astA, ecpA-B, ecpD-E, ecpR, espL1, espL4, espX5, fimB-C, fimF-G, fimI, hlyE, iss, iucA, sitA-C

  • PO169c

  • –:H2

  • 2015 surveillance study

 IncX1, IncI2, IncFII(pCoo), IncB/O/K/Z 59.2 90 99 acrRb, phoPb, mcr-1 blaTEM-1, gyrAb, qnrS1, tetA aec31-32, ecpA-E, ecpR, espR1, fimA-C, fimE-I, hlyE, ibeC, iss, mchF, tia

Bold formatting indicates the Inc type of the mcr-1-harbouring plasmid.

a

Estimated from size of mcr-1-containing contigs present in WGS and plasmid profiling, as described previously.

b

Indicates the presence of non-synonymous SNPs on chromosomal genes that may result in AMR.

c

WGS accession number PRJEB13576.