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Demethylation of CNS2 by low oxygen conditions is TET2/3 dependent. (A) Foxp3 stability in TET2/3-deficient (DKO) iTregs. iTregs were induced from naive T cells isolated from WT or DKO mice for 5 days under the 5% O2 condition, then cultured for a further 3 days under the Th1 condition. Foxp3 positivity of T cells was determined by flow cytometry. (B) Methylation status determined by the bisulfite conversion of the CpG sites of Foxp3 CNS2.
