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Induction of pyroptosis mediated by gasdermin-D. Pathogen-derived PAMPs or physiological aberrations (DAMPs) activate inflammatory caspases. These caspases cleave gasdermin-D to separate its N- and C-terminal domains. The N-terminal domain of gasdermin-D is targeted to the membrane and assembles large, permeable pore complexes in the plasma membrane of the cell to induce pyroptosis.
