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. Author manuscript; available in PMC: 2018 Apr 9.
Published in final edited form as: Cell Metab. 2017 Jul 5;26(1):17–23. doi: 10.1016/j.cmet.2017.05.014

Figure 1. Glycogen is present in human β-cells in diabetes.

Figure 1

Representative electron micrograph showing glycogen in a β-cell of a type-2 diabetic organ donor with diet-controlled diabetes (HbA1c, 6.6) for 10 years. Sample prepared and stained for glycogen (Brereton et al 2016). Glycogen particles (gly, electron dense material) were distributed throughout the cytoplasm in most β-cells. Autophagic bodies and lysosomes (inset, lys) also contained glycogen. Insulin granules (Ins) contained either dark crystalline cores (mature) or less electron dense material (immature). Scale bar, 1µM. Scale bar of inset 0.5µM.