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. Author manuscript; available in PMC: 2018 Apr 9.
Published in final edited form as: Cell. 2012 Mar 16;148(6):1160–1171. doi: 10.1016/j.cell.2012.02.010

Figure 2. Impaired glucose-induced insulin secretion cannot be accounted for by reduced insulin content.

Figure 2

(A) Insulin content in islets from non-diabetic (ND) and age- and BMI-matched T2DM organ donors). (B) Insulin secretion, normalized to islet insulin content, evoked by 1mM and 20mM glucose in ND and T2DM islets. Mean±s.e.m. (C) Stimulation index (insulin secretion at 20mM glucose divided by that at 1mM) in ND and T2DM islets *p<0.05 versus 1mM glucose; †p<0.05 vs. ND islets. From: Walker et al. (2011)