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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Cancer Res. 2018 Feb 1;78(7):1833–1844. doi: 10.1158/0008-5472.CAN-17-2069

Fig. 3. High expression of serum exosomal miR-1246 is associated with advanced pathological stage and localized PCa metastasis.

Fig. 3

A. Relative ex-miR-1246 expression in exosomes derived from the sera of PCa patient training cohort (cohort 2) as assessed by real-time PCR. RNU6A was used as an endogenous control. Patients with BPH (n=21) were used as calibrators.

B. Correlation of serum exosomal miR-1246 expression with clinicopathological parameters in PCa patients. P-values are based on Chi square test.

C. Correlation of serum exosomal miR-1246 expression with prognostic risk groups IIA-IV as defined by American Joint Committee on Cancer. P-values are based on Chi square test.

D. ROC curve analyses for ex-miR-1246 expression (left panel) and PSA (right panel) as parameters to discriminate between non-metastatic and localized metastatic PCa cases Analyses was based on dCT values of ex-miR-1246 in training cohort (1 and 2, n=77) that included lymph node metastatic PCa (n=26), non-metastatic PCa (n=43) and normal (n=8) individuals.