Table 2.

Characteristics of perfusion imaging-based treatment studies in the meta-analysis

Study	Design	Sample size		Max time window (hours)		Age		Baseline NIHSS		Time to rescan (hours)	Recanalization (%)		Symptomatic ICH (%)
		PI	Control	PI	Control	PI	Control	PI	Control		PI	Control	PI	Control
Bivard et al, 201510	Prospective cohort	366	396	4.5	4.5	73†	74†	14†	12†	24	NR	NR	5	5
García-Bermejo et al, 201211	Prospective case controlled	43	172	No limitation (range 4.5–14; 16 patients unknown onset)	4.5	69	72	9†	11†	1, 2, 24	65	77	4.7	2.3
Jovin et al, 201112	Retrospective cohort	198	121	8–26; 14 patients unknown onset	6‡	65	64	15†	17†	NR	74	66	10	10
Morelli et al, 201513	Prospective cohort	27	143	Unknown onset	4.5	72.2	71.3	11.9	11.4	NR	NR	NR	0	3.4
Obach et al, 201114	Prospective cohort	106	262	4.5	3	73.3†	73†	9†	10†	NR	NR	NR	5	7
Prabhakaran et al, 201415	Retrospective cohort	76	138	8	8	74.4*	64.4	18†	19†	NR	62.5*	47.1	5.3	12.3
Rai et al, 201316	Retrospective cohort	99	430	No limitation (range 3–9)	3–8§	69	67 68.1 63.5*	17	20.1*§ 19.1*§ 17.6§	NR	55.6	27.7 68 81.6*	NR	NR
Sztriha et al, 201117	Prospective cohort	79	157	3–6	3	74	74	13	14	24	NR	NR	4	3

^*p<0.05.

^†Median value reported instead of mean value.

^‡Control from PROACT-II trial patients who were randomized to treatment group.

^§Control from MERCI, Multi-MERCI, Penumbra pivotal trials, respectively.

ICH, intracranial hemorrhage; NIHSS, National Institutes of Health Stroke Scale; NR, not reported; PI, perfusion imaging group.