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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Mol Cancer Res. 2017 Feb 27;15(7):884–895. doi: 10.1158/1541-7786.MCR-16-0444

Figure 1. VCAN expression and it’s correlation with prognosis in ccRCC.

Figure 1

(A) Representative immunoblot displaying VCAN expression in HK-2, Caki-2, ACHN and 786-O cells. VCAN protein was upregulated in RCC cell lines in comparison with that of HK-2. GAPDH used as loading control. (B) mRNA expression of VCAN in 84 matched clinical samples. ccRCC samples showed a significantly higher level of VCAN expression in comparison with normal renal tissues. ***, P<0.001. (C) Representative VCAN staining (left) and scoring (right) of available clinical samples. VCAN protein expression in ccRCC samples was significantly higher than that of normal kidney tissues. ***, P<0.001. (D) Kaplan-Meier curves for 5-year overall survival (OS) after radical nephrectomy. Left: Patients with high VCAN expression were significantly associated with lower 5-year OS (P=0.0139). Right: Stratification of VCAN expression with tumor stage identified a stepwise reduction of 5-year OS rate.